: A brilliant but mentally ill inmate known for his intense focus and tragic storyline. Sarah Wayne Callies (Dr. Sara Tancredi)

While the brothers were the car, the supporting cast was the engine. The "Fox River Eight" (the group of escapees) featured some of the most memorable character actors of the era.

Wentworth Miller is the lead actor of Prison Break , widely known for his portrayal of , the brilliant engineer who tattoos an escape plan onto his body to save his brother. Since the show's 2005 debut, Miller has transitioned from a global television star to a prominent advocate for mental health and LGBTQ+ rights. Career & Performance as Michael Scofield

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If you ask fans who the most memorable is, many will say Robert Knepper. T-Bag is a racist, pedophilic, cannibalistic murderer. He is, by all accounts, the most despicable character on network television. Yet, Knepper made him fascinating.